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| LEITE,C.V.S.; NARESSE,L.E.; ARANTES,H.L.; LOPES,A.F.; THOMAZINI-SANTOS,I.A.; GIANNINI,M.J.S; MERCADANTE,M.C.; BARRAVIERA,B.; KOBAYASI,S.. |
| The objective of this study was to evaluate the efficacy of fibrin adhesive made up of snake venom and bubaline fibrinogen by rat colon anastomosis. Eighty rats were randomly assigned into 2 experimental groups: GI control (anastomosis with extramucous interrupted suture) and GII (repair suture + fibrin glue). The animals were studied at the following 4 times: T0 preoperative, T1 7th day postoperative, T2 14th day postoperative, and T3 21 st day postoperative. The macroscopic characteristics of the intestinal segment open and closed anastomosis and the bursting strength of the anastomosed segments were observed at each of the above times. The results showed that the anastomosed segments coapted and there was no difference in the bursting strength... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fibrin glue; Experimental healing; Bursting strength; Experimental anastomosis; Snake venom; Colon anastomosis. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302000000200004 |
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| Ferraro,G. C.; Moraes,J. R. E.; Pereira,G. T.; Moraes,F. R.; Bueno de Camargo,M. H.. |
| The aim of this study was to evaluate the effect of snake venom derived fibrin glue on the healing of the deep digital flexor tendon, during three periods. The tendon of the 2nd digit of 30 thoracic limbs of dogs was partially sectioned for glue application. Biopsies were performed 7, 15, and 30 days post surgery for the clinical and morphological study of tendons. Analysis of the results showed that 73.3% of the tendons showed stump retraction and 16.6% moderate to excessive adherence, which affected sliding. There was a significant difference in the number of inflammatory cells among the three studied periods, being the highest on day 15. The morphological analysis revealed a typical tendon healing process with a lower level of inflammation in the acute... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Dog; Fibrin glue; Snake venom; Healing; Tendon. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000400005 |
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| Ferraro,G. C.; Moraes,J. R.; Shimano,A. C.; Pereira,G. T.; Moraes,F. R.; Bueno de Camargo,M. H.. |
| The aim of this study was to evaluate the effect of snake venom derived fibrin glue on the strength oftendon healing in dogs. The deep digital flexor tendon of the 5th digit of 24 thoracic limbs was partially sectioned for adhesive application. On the 7th, 15th, and 30th postoperative day tendons segments were removed for the clinical and biomechanical study. Results indicated that 62.5% of the tendons showed stump retraction and 20.8% moderate to excessive adherence, which affected gliding. The biomechanical evaluation showed that, over time, tendon healing gained progressive resistance for maximum traction and permanent deformations with satisfactory results on the 15th day for rigidity and resilience compared to the other two studied periods. Snake... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dog; Fibrin glue; Mechanical properties; Snake venom; Healing; Tendon. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000300005 |
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| Moraes,J.R.E.; Correia,P.H.A.; Camplesi,A.C.; Moraes,F.R.. |
| This study evaluated the use of fibrin glue derived from snake venom in the healing process after canine hysterorrhaphy. Three groups of four animals were submitted to uterine hysterotomy followed by wound closure. In Group 1, double-layer suture was used, the first with Schimieden pattern, the second with Cushing pattern; in Group 2, only fibrin glue; and in Group 3, the same as for Group 1 but with fibrin glue as suture reinforcement. Results indicated that fibrin glue produced less inflammation in the exudative phase, and exacerbated deposition of connective tissue and angiogenesis in the proliferative and maturation phases of the healing process, favoring its evolution. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Healing; Fibrin glue; Uterus; Surgical adhesives; Wound closure. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992004000200003 |
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| THOMAZINI-SANTOS,I. A.; BARRAVIERA,S. R. C. S.; MENDES-GIANNINI,M. J. S.; BARRAVIERA,B.. |
| The authors have performed a literature review of surgical adhesives, such as cyanoacrylate, collagen gelatin, and fibrin glue. They have included different types of commercial and non-commercial fibrin sealants and have reported on the different components in these adhesives, such as fibrinogen, cryoprecipitate, bovine thrombin, and thrombin-like fraction of snake venom. |
| Tipo: Info:eu-repo/semantics/review |
Palavras-chave: Fibrin glue; Surgical adhesives; Collagen gelatin; Cyanoacrylates; Fibrinogen; Cryoprecipitate; Bovine thrombin; Thrombin-like fraction; Snake venom. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302001000200002 |
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| CHALHOUB,M.; PRESTES,N. C.; LOPES,M. D.; ROCHA,N. S.; THOMAZINI-SANTOS,I. A.; MENDES-GIANNINI,M.J.. |
| Fibrin glue has been used on its own or in conjunction with suturing materials to promote hemostasis, reduce adherence, strengthen the wound site, and improve healing. Snake venom derived fibrin glue was evaluated as an alternative to conventional uterine suturing after ovine caesarean surgery. Twenty-eight pregnant ewes of known mating date were used. The animals submitted to conventional caesarean sections showed a better wound healing process. As expected, all the operated animals had retained placenta, compromising coaptation of wound edges. This had a strong influence in the results observed with the animals in which fibrin glue was used. The animals were divided into four groups GI, GII, GIII, and GIV and sacrificed, respectively, 3, 7, 15, and 30... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fibrin tissue adhesive; Viper venoms; Uterus/sutures; Sheep; Fibrin glue. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302000000200007 |
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| Sampaio,R. L.; Ranzani,J. J. T.; Brandão,C. V. S.; Thomazini-Santos,I. A.; Barraviera,B.; Barraviera,S. R. C. S.; Giannini,M. J. S. M.. |
| Fibrin glue has been researched as an alternative method for tissue synthesis and is known for its capability to promote hemostasis at the application site, good approximation of wound edges and fast healing. The current study consisted in the application of fibrin glue derived from snake venom as treatment for experimental corneal ulcers. Twenty-one dogs had their corneas experimentally prepared through lamellar keratectomy (of standardized diameter and depth). Animals were divided into seven groups of three animals each. Six experimental groups were periodically evaluated and collection was carried out on the 1st, 3rd, 7th, 15th, 30th and 60th post-operative days, whereas one control group was evaluated throughout the experiment. Analyses consisted in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fibrin glue; Snake venom; Cornea; Corneal ulcer; Keratoplasty. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000400014 |
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